International Journal of Advanced Chemistry Research

International Journal of Advanced Chemistry Research

Online ISSN: 2664-679X
Print ISSN: 2664-6781

International Journal of Advanced Chemistry Research
Online and Print Journal   |   Indexed Journal   |   Refereed Journal   |   Peer Reviewed Journal
International Journal of Advanced Chemistry Research
2019, Vol. 1, Issue 1
Solubility enhanced Nevirapine and it’s use in various forms

M Ranga Priya, NN Rajendran

The aim of present study was solubility enhancement of nevirapine by using different solubilization methods like solid dispersion, hydrotropy and micellar solubilization. Solubility of nevirapine as pure drug and in other forms such as physical mixture, solid dispersions were analyzed using different carriers. Hydrotropic and micellar solubilization techniques were performed with variable concentrations of surfactants. Neviapine solubility enhancement was found to be in the order of micellar solubilization >hydrotropic solubilization > solid dispersion. Increasing the concentration of the solubilizer increased the solubility of the drug. Sodium lauryl sulphate enhanced the solubility of nevirapine to greater levels when compared to other solubilising agents.
Pages : 33-36 | 267 Views | 130 Downloads
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