Mohammad Asif, Abida, Md Tauquir Alam
Various heterocyclic analogues were found to possess promising pharmacological activities. Various indole analogues are also attracted the attention of researchers because of the diverse biological activities. Indole nucleus is present in many natural as well as synthetic products. Due to its wider applications the indole analogues, they will replace many existing heterocyclic based pharmaceutical products. Now days, various drugs are in market and several are in clinical trials. Various indole analogues were identified as a privileged structure of pharmacophore and possess broad spectrum of biological and pharmaceutical activities such as anticancer, antihypertensive, antidepressant, antipsychotic, anti-inflammatory, antiemetic, analgesic, anti-asthmatic, antiviral, anti-arrhythmic, β-blocker, inhibitor of RNA polymerase-11, agonist for the cannabinoid receptor, non- nucleoside reverse transcriptase inhibitor, opioid agonist and sexual dysfunction etc. Indole derivatives have been special interest to organic and medicinal chemists.
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