Y Aparna, NJP Subhashini, LN Sharada
Several imidazole-based clinical drugs play imperious site in handling numerous diseases. Novel imidazoles with therapeutic values are being belligerently subjugated worldwide. Imidazoles exist in tautomeric forms and bind with receptors through vanderwaals forces, hydrogen bonding, dipole-dipole and π bonding interactions thereby exhibiting broad bioactivities and therapeutic action. Molecular docking studies of these compounds unravel the mode of interaction with bacterial enzymes and antifungal action. This article aims to review the work reported on the cytotoxic activities and molecular docking studies of imidazole derivatives.
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