Vol. 3, Issue 2, Part A (2021)

The potential of marine resources that have not been much explored is sea urchin (Echinometra mathaei), which is shown to have high antioxidant activity. High antioxidant activity has a potential correlation with analgesic, antipyretic and anti-inflammatory activities. The study aims to determine the antipyretic activity of Echinometra mathaei (EM) in Balb/c mice as an animal model. This study consisted of the extraction of EM with 70% ethanol and antipyretic activity assay on albino mice which induced 10% peptone (s.c). Thirty albino mice were divided into 6 groups i.e: negative control group, positive control group, paracetamol group, extract EM 100mg/kg BW, extract EM 200mg/kg BW, extract EM 400mg/kg BW. The body temperature was observed for 1 h after extract was given p.o. The results showed that all the dosage of EM extract could reduce the elevated body temperature of the mice and the doses of 200 mg/kg BW and 400 mg/kg BW showed no significant difference with paracetamol 65 mg/kg BW (P < 0.05). Conclucion of the research was the extract of Echinometra mathaei has antipyretic activity at the doses of 100 mg, 200 mg, and 400 mg/Kg BW.