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International Journal of Advanced Chemistry Research

Vol. 5, Issue 1, Part A (2023)

Synthesis, characterization and biological evaluation of tetrazole derivatives

Author(s):

Jassim Mohammed Ali, Dhurgham Qasim Shaheed, Ali Jabbar Radhi, Haider Abbas Abdul Redha Aboud Alkhafaji and Hayder Kadhim Abbas

Abstract:
Heptanitrile was used in preparation azide β-lactam derivatives to produce a number of new derivatives contain tetrazole ring connected to the β-lactam moiety, which were then determined the chemical structure of prepared end products by using NMR and IR spectroscopy. The biological test against selected microorganisms showed that the majority of the end derivatives had good antifungal and antibacterial activity. The antifungal and antibacterial activity of the (t2) derivative in particular was equivalent to or even superior to that of the reference drugs Amoxicillin and Fluconazole.

Pages: 41-46  |  261 Views  100 Downloads

How to cite this article:
Jassim Mohammed Ali, Dhurgham Qasim Shaheed, Ali Jabbar Radhi, Haider Abbas Abdul Redha Aboud Alkhafaji and Hayder Kadhim Abbas. Synthesis, characterization and biological evaluation of tetrazole derivatives. Int. J. Adv. Chem. Res. 2023;5(1):41-46. DOI: 10.33545/26646781.2023.v5.i1a.142
International Journal of Advanced Chemistry Research

International Journal of Advanced Chemistry Research

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