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International Journal of Advanced Chemistry Research

Vol. 5, Issue 1, Part A (2023)

Evaluation of apo lipoprotein A-1 and some biochemical parameters in the blood of patients with chronic kidney disease

Author(s):

Nawal A Murtadha and Entedhar R Sarhat

Abstract:

Aim: This study was designed to determine the level of serum Apolipoprotein A-I (ApoA-I), Cystatin C, and homocysteine among three groups - CKD patients without the end- stage renal disease (ESRD), patients with ESRD on hemodialysis and healthy controls. 
Materials and Methods: A retrospective, hospital-based study was carried out from 100 patients' records from each group and serum Cystatin-C, homocysteine, apo-A1values were noted. 
Results: The duration of dialysis treatment was 31 [+ or -] 35 months. Paired t-test analyses showed a significant increase in mean urea and creatinine, uric acid, and Cystatin C among CKD patients which then declined significantly after hemodialysis. Serum Apo-A1 and homocysteine levels were significantly higher in both hemodialysis and pre-dialysis groups compared to control subjects.
Conclusion: HD increases apoA1 and Cystatin C whereas decreases HCM and uric acid as both are antagonists that might play a vital role in the pathogenesis of related disorders in CKD Patients.
 

Pages: 50-54  |  373 Views  143 Downloads


International Journal of Advanced Chemistry Research
How to cite this article:
Nawal A Murtadha and Entedhar R Sarhat. Evaluation of apo lipoprotein A-1 and some biochemical parameters in the blood of patients with chronic kidney disease. Int. J. Adv. Chem. Res. 2023;5(1):50-54. DOI: 10.33545/26646781.2023.v5.i1a.144
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