Vol. 5, Issue 2, Part A (2023)

Sulfamethoxazole (SMZ), a sulfonamide antibiotic that is widely used and frequently found in aquatic environments, has been chosen as a representative of this class of drugs. As an alternate group or as an alternative to another loop, the thiazolidenone ring has been incorporated into a broad variety of bioactive compounds, leading researchers to create several molecules that contain this component. Chalk chemistry also resulted in significant scientific readings all around the world. The construction and biodynamic processes of the Calcone have received the majority of attention in order to enable the development of several new heterogeneous cycles with suitable medicinal forms. Seven distinct aliphatic and aromatic molecules were employed in the successful development of synthetic processes to produce target compounds.