Vol. 6, Issue 1, Part A (2024)

Myocardial infarction (MI) is a medical emergency, life-threatening, time-sensitive and non-infectious that occurs due to ischemia or stoppage of perfusion caused by pathological changes or abnormalities in the walls of coronary arteries which the coronary arteries cannot supply to part to the heart for long periods, causing damage to the heart tissue and its possible death. The aim of the present study was to the measure concentration of paraoxonase-1 (PON1) enzyme and creatine kinase (CKMB) enzyme in patients with acute myocardial infarction (AMI), acute myocardial infarction with diabetes mellitus (AMI+DM)) and controls, as well identify the association between the parameters that were measured and the increased risk of cardiovascular (CV) risk of MI patients. This study that was done during two months, in Iraq which enrolled 100 sample for persons who met the participation criteria from patients and controls. The statistical evaluation was achieved with the aid of a statistical package for social sciences (SPSS ). Where this study found PON1 level raised in the total of patients significantly at (P = 0.001), CKMB concentration increased highly significant in the serum total of patients (P = 0.0003), when compared between patients and healthy and according to T-Test analysis. The conclusion of this study is increased concentration of PON1 and CKMB with statistical differences significant appeared in AMI and (AMI + DM) patients compared to the control group. Correlation analysis revealed no statistically significant correlation between concentrations of the PON1 and CKMB (r = -0.140, P = 0.258).