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NAAS Journal
International Journal of Advanced Chemistry Research

Vol. 7, Issue 1, Part A (2025)

Development of a sensitive spectrophotometric method for the quantification of ketotifen fumarate in aqueous solutions via diazotization of 4-aminoantipyrene

Author(s):

Mustafa M Abd, Abdulhakeem Dahham Hussein and Yasser Aamer Jassim

Abstract:

This study introduces a novel, rapid, and highly sensitive spectrophotometric method for the quantification of Ketotifen fumarate in aqueous solutions. The presented method involves the diazotization of 4-aminoantipyrene utilizing sodium nitrate in an acidic medium, followed by the subsequent coupling of the diazonium compound with Ketotifen in a basic environment. The resultant orange azo dye demonstrates a peak absorbance at 483 nm and possesses solubility and stability in aqueous solution for over 60 minutes. The absorbance of the dye exhibits a linear response within the concentration range of 1–10 µg/mL, with a molar absorptivity of 11,943.84 L·mol⁻¹·cm⁻¹ and a Sandell's sensitivity index of 0.0259 µg/mL. The method conveys exceptional accuracy, with results ranging between 98% and 100.16%, and has been successfully utilized for the analysis of pharmaceutical formulations.

Pages: 11-17  |  97 Views  44 Downloads


International Journal of Advanced Chemistry Research
How to cite this article:
Mustafa M Abd, Abdulhakeem Dahham Hussein and Yasser Aamer Jassim. Development of a sensitive spectrophotometric method for the quantification of ketotifen fumarate in aqueous solutions via diazotization of 4-aminoantipyrene. Int. J. Adv. Chem. Res. 2025;7(1):11-17. DOI: 10.33545/26646781.2025.v7.i1a.249
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