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NAAS Journal
International Journal of Advanced Chemistry Research

Vol. 7, Issue 1, Part A (2025)

Estimation of Galanin hormone levels and additional biochemical markers in polycystic ovary syndrome patients

Author(s):

Sheerin Farouq Shaker

Abstract:

Polycystic ovarian syndrome (PCOS), which is typified by irregular menstrual cycles, hyperandrogens, and polycystic ovaries, is the most prevalent endocrine and metabolic disorder affecting premenopausal women. Women with PCOS are more likely to develop metabolic syndrome because they are at a higher risk of acquiring hypertension and dyslipidemia. 
Twenty health screen examinees who were admitted to the Tikrit Teaching Hospital's primary accommodations between January and March 2024 were referred to our organization. Forty patients were selected on the basis of their history of Polycystic Ovarian Syndrome, blood test results, abdominal ultrasound results, and whether or not they provided written informed consent. For those who have Polycystic Ovary Syndrome, blood galanin levels were significantly elevated, independent of age or the results of laboratory tests (144.9±9.2vs. 30.18±6.6, p<0.01) and serum Irsin levels (6.1±0.6 vs. 0.9±0.3, p<0.01). Polycystic Ovary Syndrome patients exhibited significantly higher mean serum 8 Oxoguanine DNA glycosylase levels than the control group (13.6± o.4 versus 2.3± 0.3 (p>0.01). Polycystic Ovary Syndrome patients had significantly higher serum hormones (TSH, Prolactin, LH and FSH) compared to controls (0.05±0.02 versus 2.29± 0.8), (35.5±3.5 versus11.2±3.8), (17.7±1.5 versus 9.07±2.7) and (28.01±3.8 versus 9.6±1.5) respectively with p values <0.01. As well as Patients with Polycystic Ovary Syndrome had significantly higher Lipid profiles (Cholestrol, Triglyceride) and D3 concentrations compared to controls (294.2±22.2versus 92.1±4.7, 212.4±6.4 versus 73.6±9.4) and (8.1±2.0versus 51.8±9.2) respectively with p-values < 0.01.
Aim of the study: This study aimed to evaluate the lipid profile (Cholestrol, triglycerides), blood levels of galanin and irisin, hormone levels (TSH, prolactin, LH, and FSH), and D3 concentrations in individuals with Polycystic Ovary Syndrome condition and compare them to control groups.
 

Pages: 32-42  |  75 Views  20 Downloads


International Journal of Advanced Chemistry Research
How to cite this article:
Sheerin Farouq Shaker. Estimation of Galanin hormone levels and additional biochemical markers in polycystic ovary syndrome patients. Int. J. Adv. Chem. Res. 2025;7(1):32-42. DOI: 10.33545/26646781.2025.v7.i1a.254
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