Vol. 7, Issue 11, Part A (2025)

A series of new heterocyclic derivatives containing benzo[d]imidazole scaffolds was synthesized through a multi-step reaction procedure. Initially, ethyl 2-(1H-benzo[d]imidazol-1-yl) acetate was obtained from benzimidazole and ethyl 2-chloroacetate in ethanol. Subsequent treatment with hydrazine hydrate afforded 2-(hydrazinyloxy)-2-oxoethyl-1H-benzo[d]imidazole, which was converted to 2-(1H-benzo[d]imidazol-1-yl) acetohydrazide. The hydrazide was then condensed with benzaldehyde to give the corresponding Schiff base, (E)-2-(1H-benzo[d]imidazol-1-yl)-N-benzylideneacetohydrazide. Further cyclization under microwave irradiation in the presence of chloramine-T as a catalyst furnished 2-((1H-benzo[d]imidazol-1-yl) methyl)-5-phenyl-1, 3, 4-oxadiazole. This multistep microwave-assisted synthetic procedure providing an accelerated and sustainable approach with improved reaction efficiency. This synthetic route provides an efficient and convenient strategy for the preparation of bioactive benzimidazole-oxadiazole hybrids (T_1-T₅), which are of potential interest in medicinal chemistry due to their diverse pharmacological properties. Characterisation of synthesized compound (T_1-T₅) were confirmed by using IR (KBr), H-1 NMR spectral data, and reaction completion was monitor by using TLC.