Vol. 7, Issue 11, Part A (2025)

Over the last decade, deep eutectic solvents (DESs) have gained recognition as a promising alternative to conventional organic solvents, from both environmental as well as technological perspectives. Due to its inherent biological properties these eutectic solvents serve as ideal reaction media with whole cells and isolated enzymes which have shown improved enzyme stability and activity translating to high conversion of product. In this article, we have reported Baker’s yeast (saccharomyces cerevisiae) catalyzed one-pot three component condensation of aryl aldehydes, thioglycolic acid, and amines in deep eutectic solvent leading to 4-thiazolidinones successfully. This article presents a successful one-pot three-component condensation of aryl aldehydes, amines and thioglycolic acid, catalyzed by Baker’s yeast (Saccharomyces cerevisiae) in a deep eutectic solvent, leading to the efficient synthesis of 4-thiazolidinones. The chloride-based deep eutectic solvent (DES) used in this methodology can be effectively reused and recycled up to five consecutive runs without any significant loss in catalytic activity.