Vol. 7, Issue 10, Part A (2025)

The 1,3,5-triazine scaffold is a versatile heterocyclic platform with wide applications in medicinal and materials chemistry. In this work we report the design, synthesis, and comprehensive spectral characterization of a novel library of 1,3,5-triazine derivatives functionalized with a range of substituted amines. Target compounds were prepared via controlled nucleophilic substitution on a tris-activated triazine precursor under mild conditions, enabling systematic variation of electronic and steric properties at the three substitution sites. Purification was achieved by recrystallization and/or column chromatography. Structural confirmation was obtained from FT-IR (diagnostic triazine ring and amine vibrations), and multinuclear NMR (¹H and ¹³C) showing expected chemical shifts, coupling patterns, and integration for each derivative. Elemental analysis further supported composition.